Variants in genes encoding small GTPases and association with epithelial ovarian cancer susceptibility.
Epithelial ovarian cancer (EOC) is the fifth leading cause of cancer mortality in American women.Normal ovarian physiology is intricately connected to small GTP binding proteins of the Ras superfamily (Ras, Rho, Rab, Arf, and Ran) which govern processes such as signal transduction, cell proliferation, cell motility, and vesicle transport.We hypothe